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Article

Sphingosine 1-phosphate signaling axis mediates neuropeptide S-induced invasive phenotype of endometriotic cells.

The FEBS journal - 1 Apr 2024

Prisinzano Matteo, Bernacchioni Caterina, Seidita Isabelle, Rossi Margherita, Raeispour Maryam, Cencetti Francesca, Vannuccini Silvia, Fambrini Massimiliano, Petraglia Felice, Bruni Paola, Donati Chiara

Abstract excerpt

Endometriosis is a chronic gynecological syndrome characterized by endometrial cell invasion of the extra-uterine milieu, pelvic pain and infertility. Treatment relies on either symptomatic drugs or hormonal therapies, even though the mechanism involved in the onset of endometriosis is yet to be elucidated. The signaling of sphingolipid sphingosine 1-phosphate (S1P) is profoundly dysregulated in endometriosis....

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PMID: 38287231
DOI: 10.1111/febs.17071

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NPS

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