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Article

Age-related function of tumor suppressor gene TP53:contribution to cancer risk and progression.

Experimental oncology - 1 Sept 2010

Cherdyntseva N V, Gervas P A, Litvyakov N V, Stakcheeva M N, Ponomaryeva A A, Dobrodeev A Yu, Denisov E V, Belyavskaya V A, Choinzonov E L

Abstract excerpt

AIM: To examine the influence of combined genotypes of TP53 (exon 4, intron 3, intron 6) and XRCC1 (codon 10) on lung cancer age of onset. METHODS: TP53 polymorphisms in codon 72 of exon 4 (Arg72Pro), in intron 3 (16 bp duplication), in intron 6 (G/A transition) and XRCC1 polymorphism in codon 10 (Arg399Gln) were analyzed in blood cells of 177 lung cancer patients and 196 healthy donors with Restriction Fragment...

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PMID: 21403619

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XRCC1

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