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Article

Germline genetics of the p53 pathway affect longevity in a gender specific manner.

Current aging science - 1 Jan 2014

Groß Sebastian, Immel Uta-Dorothee, Klintschar Michael, Bartel Frank

Abstract excerpt

Aging is thought to occur through the accumulation of molecular and cellular damage. A key regulator of the cell's stress response is p53. In mice, the activity of p53 associates with lifespan. We were therefore interested whether SNPs in members of the p53-pathway are associated with longevity in humans. We genotyped the following SNPs: p53 - rs1042522 (Arg72Pro), MDM2 - rs2279744 (SNP309), MDM4 - rs4245739...

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Source

Identifiers

PMID: 24654968
DOI: 10.2174/1874609807666140321150751

Genes

MDM4
MDM2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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