Germline genetics of the p53 pathway affect longevity in a gender specific manner.

doi:10.2174/1874609807666140321150751

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Article

Germline genetics of the p53 pathway affect longevity in a gender specific manner.

Current aging science - 1 Jan 2014

Groß Sebastian, Immel Uta-Dorothee, Klintschar Michael, Bartel Frank

Abstract excerpt

Aging is thought to occur through the accumulation of molecular and cellular damage. A key regulator of the cell's stress response is p53. In mice, the activity of p53 associates with lifespan. We were therefore interested whether SNPs in members of the p53-pathway are associated with longevity in humans. We genotyped the following SNPs: p53 - rs1042522 (Arg72Pro), MDM2 - rs2279744 (SNP309), MDM4 - rs4245739...

Topics

Age Factors
Aged, 80 and over
Case-Control Studies
Cell Cycle Proteins
Female
Gene Frequency
Genotype
Humans
Kaplan-Meier Estimate
Longevity
Male
Nerve Tissue Proteins
Nuclear Proteins
Phenotype
Polymorphism, Single Nucleotide
Protein Phosphatase 2
Proto-Oncogene Proteins
Proto-Oncogene Proteins c-mdm2

Source

Open in PubMed

Identifiers

PMID: 24654968
DOI: 10.2174/1874609807666140321150751

Genes

MDM4
MDM2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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