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Article

OAS1 splice site polymorphism controlling antiviral enzyme activity influences susceptibility to type 1 diabetes.

Diabetes - 1 May 2005

Field L Leigh, Bonnevie-Nielsen Vagn, Pociot Flemming, Lu Shao, Nielsen Thomas B, Beck-Nielsen Henning

Abstract excerpt

Both genetic and nongenetic factors contribute to the development of type 1 diabetes. Many investigations, including prospective studies of high-risk children, have implicated virus infections as predisposing environmental agents. We previously reported that basal activity of the key antiviral enzyme 2'5'-oligoadenylate synthetase (2'5'AS) was significantly elevated in type 1 diabetic patients compared with...

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Source

Identifiers

PMID: 15855350
DOI: 10.2337/diabetes.54.5.1588

Genes

OAS1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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OAS1 splice site polymorphism controlling antiviral enzyme activity influences susceptibility to type 1 diabetes.PMID 15855350Read ↗

Variation in antiviral 2',5'-oligoadenylate synthetase (2'5'AS) enzyme activity is controlled by a single-nucleotide polymorphism at a splice-acceptor site in the OAS1 gene.Semantic proximity Read ↗

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