Article
Novel mutations of the suppressor gene PTEN in colorectal carcinomas stratified by microsatellite instability- and TP53 mutation- status.
Human mutation - 1 Nov 2008
Danielsen Stine A, Lind Guro E, Bjørnslett Merete, Meling Gunn I, Rognum Torleiv O, Heim Sverre, Lothe Ragnhild A
Abstract excerpt
PTEN regulates cell homeostasis by inhibiting growth signals transduced through PI3-kinases. The gene is mutated in several cancer types, but so far, only a limited number of mutations have been reported in colorectal cancer. In the present study, direct sequencing was used to analyze the whole coding region and exon-intron boundaries of PTEN in a series of microsatellite stable (n=34) and microsatellite unstable...
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