Article
Chromosome number and structure both are markedly stable in RER colorectal cancers and are not destabilized by mutation of p53.
Oncogene - 13 Aug 1998
Eshleman J R, Casey G, Kochera M E, Sedwick W D, Swinler S E, Veigl M L, Willson J K, Schwartz S, Markowitz S D
Abstract excerpt
Fourteen colorectal cancer cell lines, categorized according to the presence or absence of microsatellite instability, were further analysed for chromosomal stability by karyotyping. NonRER (microsatellite stable) cell lines typically displayed highly aberrant karyotypes with alterations not only...
Topics
- Chromosome Aberrations
- Chromosomes
- Colorectal Neoplasms
- DNA Replication
- DNA, Neoplasm
- Humans
- Karyotyping
- Microsatellite Repeats
- Mutation
- Tumor Cells, Cultured
- Tumor Suppressor Protein p53