Article
Heterogeneity studies identify a subset of sporadic colorectal cancers without evidence for chromosomal or microsatellite instability.
Oncogene - 23 Dec 1999
Georgiades I B, Curtis L J, Morris R M, Bird C C, Wyllie A H
Abstract excerpt
Two apparently independent mechanisms of instability are recognized in colorectal cancer, microsatellite instability and chromosomal instability. Evidence from colorectal cancer cell lines indicates the presence of either, or both, types of instability in the vast majority. Here, we sought to determine the prevalence of such instability in primary sporadic colorectal cancers. Microsatellite instability was...
Topics
- Aged
- Aged, 80 and over
- Aneuploidy
- Animals
- Cell Nucleus
- Chromosome Aberrations
- Chromosome Disorders
- Chromosomes, Human
- Colonic Neoplasms
- Colorectal Neoplasms
- DNA, Neoplasm