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Article

Direct production of ivermectin-like drugs after domain exchange in the avermectin polyketide synthase of Streptomyces avermitilis ATCC31272.

Organic & biomolecular chemistry - 21 Aug 2003

Gaisser Sabine, Kellenberger Laurenz, Kaja Andrew L, Weston Alison J, Lill Rachel E, Wirtz Gabriele, Kendrew Steven G, Low Lindsey, Sheridan Rose M, Wilkinson Barrie, Galloway Ian S, Stutzman-Engwall Kim, McArthur Hamish A, Staunton James, Leadlay Peter F

Abstract excerpt

Ivermectin, a mixture of 22,23-dihydroavermectin B1a9 with minor amounts of 22,23-dihydroavermectin B1b 10, is one of the most successful veterinary antiparasitic drugs ever produced. In humans, ivermectin has been used for the treatment of African river blindness (onchocerciasis) resulting in an encouraging decrease in the prevalence of skin and eye diseases linked to this infection. The components of ivermectin...

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PMID: 12968333
DOI: 10.1039/b304022d

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Source receipt: pubmed, retrieved 7 Sept 2026.

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Direct production of ivermectin-like drugs after domain exchange in the avermectin polyketide synthase of Streptomyces avermitilis ATCC31272.PMID 12968333Read ↗

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