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Genome mining of the <i>Streptomyces avermitilis</i> genome and development of genome-minimized hosts for heterologous expression of biosynthetic gene clusters

28 Aug 2013

Abstract excerpt

To date, several actinomycete genomes have been completed and annotated. Among them, Streptomyces microorganisms are of major pharmaceutical interest because they are a rich source of numerous secondary metabolites. S. avermitilis is an industrial microorganism used for the production of an anthelmintic agent, avermectin, which is a commercially important antiparasitic agent in human and veterinary medicine, and...

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PMID: 23990133
DOI: 10.1007/s10295-013-1327-x

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