Construction of ivermectin producer by domain swaps of avermectin polyketide synthase in Streptomyces avermitilis.

doi:10.1007/s00253-006-0361-2

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Article

Construction of ivermectin producer by domain swaps of avermectin polyketide synthase in Streptomyces avermitilis.

Applied microbiology and biotechnology - 1 Oct 2006

Zhang Xiaolin, Chen Zhi, Li Meng, Wen Ying, Song Yuan, Li Jilun

Abstract excerpt

Ivermectin, 22, 23-dihydroavermectin B1, is commercially important in human, veterinary medicine, and pesticides. It is currently synthesized by chemical reduction of the double bond between C22 and C23 of avermectins B1, which are a mixture of B1a (>80%) and B1b (<20%) produced by fermentation of Streptomyces avermitilis. The cost of ivermectin is much higher than that of avermectins B1 owing to the necessity of...

Topics

Genetic Engineering
Ivermectin
Molecular Structure
Mutation
Plasmids
Polyketide Synthases
Polymerase Chain Reaction
Streptomyces

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PMID: 16708195
DOI: 10.1007/s00253-006-0361-2

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