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Article

Comparative transcriptome analysis of doramectin-producing Streptomyces avermitilis N72 and its mutant strains.

World journal of microbiology & biotechnology - 1 Jun 2024

Pan Xiaojun, Cai Jun

Abstract excerpt

Doramectin, an essential animal anthelmintic, is synthesized through the fermentation process of Streptomyces avermitilis. This study delves into the transcriptomic profiles of two strains, namely the doramectin-producing wild-type S. avermitilis N72 and its highly doramectin-producing mutant counterpart, S. avermitilis XY-62. Comparative analysis revealed 860 up-regulated genes and 762 down-regulated genes in...

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Identifiers

PMID: 38822927
DOI: 10.1007/s11274-024-04028-5

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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