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Article

Construction of a doramectin producer mutant from an avermectin-overproducing industrial strain of Streptomyces avermitilis.

Canadian journal of microbiology - 1 Dec 2009

Zhao Xuejin, Wang Yuanxin, Wang Shiwei, Chen Zhi, Wen Ying, Song Yuan

Abstract excerpt

The avermectin analogue doramectin (CHC-B1), which is produced in mutants that have an altered biosynthesis pathway of avermectin, is one of the most effective agricultural pesticides and antiparasitics. We report here the construction of a bkdF olmA double-deletion mutant lacking one of the branched-chain alpha-keto acid dehydrogenase encoding genes (bkdF) and the oligomycin PKS encoding gene cluster (olmA) in...

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PMID: 20029527
DOI: 10.1139/W09-098

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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Construction of a doramectin producer mutant from an avermectin-overproducing industrial strain of Streptomyces avermitilis.PMID 20029527Read ↗

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