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Synthetic biology of avermectin for production improvement and structure diversification

29 Jan 2014

Abstract excerpt

Natural products are still key sources of current clinical drugs and innovative therapeutic agents. Since wild-type microorganisms only produce natural products in very small quantities, yields of production strains need to be improved by breaking down the precise genetic and biochemical circuitry. Herein, we use avermectins as an example of production improvement and chemical structure diversification by...

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PMID: 24478271
DOI: 10.1002/biot.201200383

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