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Article

GSTP1 and MDR1 genotypes and central nervous system relapse in childhood acute lymphoblastic leukemia.

International journal of hematology - 1 Jan 2005

Stanulla Martin, Schäffeler Elke, Arens Stefan, Rathmann Anke, Schrauder André, Welte Karl, Eichelbaum Michel, Zanger Ulrich M, Schrappe Martin, Schwab Matthias

Abstract excerpt

The probability of event-free survival of childhood acute lymphoblastic leukemia (ALL) approaches 80% or more with the use of modern multiagent chemotherapeutic regimens. One major contribution to this success has been reduction of the rate of central nervous system (CNS) relapses to less than 5%. However, heterogeneity is observed with regard to the incidence of CNS relapse in homogenously treated patient...

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Topics

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Share to ATP Binding Cassette Transporter, Subfamily B, Member 1
Share to Central Nervous System Neoplasms

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Glutathione S-Transferase pi

Share to Glutathione Transferase

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Share to Precursor Cell Lymphoblastic Leukemia-Lymphoma

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Source

Identifiers

PMID: 15717687
DOI: 10.1532/ijh97.e0418

Genes

GSTP1
ABCB1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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