Article
Functional C3435T polymorphism of MDR1 gene: an impact on genetic susceptibility and clinical outcome of childhood acute lymphoblastic leukemia.
European journal of haematology - 1 May 2004
Jamroziak Krzysztof, Młynarski Wojciech, Balcerczak Ewa, Mistygacz Magda, Trelinska Joanna, Mirowski Marek, Bodalski Jerzy, Robak Tadeusz
Abstract excerpt
The significance of genetic background in childhood acute lymphoblastic leukemia (ALL) is not well understood. Polymorphisms of genes encoding for xenobiotics and drug transporters are potential factors, which can influence the risk of developing ALL and its clinical outcome. P-glycoprotein (P-gp...
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