Article
Pharmacogenetics of outcome in children with acute lymphoblastic leukemia.
Blood - 15 Jun 2005
Rocha Jose Claudio C, Cheng Cheng, Liu Wei, Kishi Shinji, Das Soma, Cook Edwin H, Sandlund John T, Rubnitz Jeffrey, Ribeiro Raul, Campana Dario, Pui Ching-Hon, Evans William E, Relling Mary V
Abstract excerpt
Acquired genetic characteristics of acute lymphoblastic leukemia (ALL) cells are used to individualize therapy, whereas germ line genetic characteristics generally are not. We determined whether ALL outcome was related to 16 genetic polymorphisms affecting the pharmacodynamics of antileukemic age...
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