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Article

Impact of CYP1A1, GSTP1 and XRCC1 genes polymorphisms on toxicity and response to chemotherapy in childhood acute lymphoblastic leukemia.

Journal of the Egyptian National Cancer Institute - 1 Sept 2017

Abo-Bakr Asmaa, Mossallam Ghada, El Azhary Nevin, Hafez Hanafy, Badawy Ragia

Abstract excerpt

BACKGROUND: Acute lymphoblastic leukemia (ALL) is the most common childhood malignancy. The interindividual genetic variations in drug metabolizing enzymes and DNA repair genes influence the efficacy and toxicity of numerous chemotherapeutic drugs affecting the treatment outcome. AIM OF THE WORK: The aim of the study was to investigate the impact of drug metabolizing CYP1, GSTP1 and DNA repair (XRCC1) genes...

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Topics

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Share to Antineoplastic Combined Chemotherapy Protocols
Share to Cytochrome P-450 CYP1A1

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Glutathione S-Transferase pi

Share to Neoplasm, Residual

Share to Pharmacogenetics

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Share to Precursor Cell Lymphoblastic Leukemia-Lymphoma

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Source

Identifiers

PMID: 28844589
DOI: 10.1016/j.jnci.2017.07.002

Genes

XRCC1
GSTP1
EFS

Provenance

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