Article
Polymorphisms within glutathione S-transferase genes in pediatric non-Hodgkin's lymphoma.
Haematologica - 1 Jul 2002
Dieckvoss Björn-Ole, Stanulla Martin, Schrappe Martin, Beier Rita, Zimmermann Martin, Welte Karl, Reiter Alfred
Abstract excerpt
BACKGROUND AND OBJECTIVES: Glutathione S-transferases (GSTs) are involved in the metabolism of a number of cancer chemotherapeutic agents. Certain members within the GST superfamily exhibit phenotypically relevant genetic polymorphisms which have been associated with outcome in hematologic malignant disease. DESIGN AND METHODS: In the present study we genotyped a cohort of 169 pediatric non-Hodgkin's lymphoma...
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