Article
Impact of glutathione S-transferase gene deletion on early relapse in childhood B-precursor acute lymphoblastic leukemia.
Haematologica - 1 Nov 2003
Takanashi Mami, Morimoto Akira, Yagi Tomohito, Kuriyama Kikuko, Kano Gen, Imamura Toshihiko, Hibi Shigeyoshi, Todo Shinjiro, Imashuku Shinsaku
Abstract excerpt
BACKGROUND AND OBJECTIVES: The glutathione-S-transferase (GST) polymorphism may affect the outcome of treatment of leukemia because GSTs play an important role in detoxifying the chemotherapeutic agents used to kill leukemia cells. However, results of previous reports have been controversial. Thi...
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