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Article

Linkage disequilibrium grouping of single nucleotide polymorphisms (SNPs) reflecting haplotype phylogeny for efficient selection of tag SNPs.

Genetics - 1 May 2005

Takeuchi Fumihiko, Yanai Kazuyuki, Morii Toshiyuki, Ishinaga Yuji, Taniguchi-Yanai Keiko, Nagano Shinobu, Kato Norihiro

Abstract excerpt

Single nucleotide polymorphisms (SNPs) have been proposed to be grouped into haplotype blocks harboring a limited number of haplotypes. Within each block, the portion of haplotypes is expected to be tagged by a selected subset of SNPs; however, none of the proposed selection algorithms have been definitive. To address this issue, we developed a tag SNP selection algorithm based on grouping of SNPs by the linkage...

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Identifiers

PMID: 15716494
DOI: 10.1534/genetics.104.038232
PMCID: PMC1449737

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