Article
The extent of linkage disequilibrium and computational challenges of single nucleotide polymorphisms in genome-wide association studies.
Current drug metabolism - 1 Jun 2011
Huang Yao-Ting, Chang Chia-Jung, Chao Kun-Mao
Abstract excerpt
Single Nucleotide Polymorphisms (SNPs) are the most abundant form of genetic variations observed in the human genome. With the advent of high-throughput genotyping arrays and next-generation sequencing (NGS) platforms, tens of millions of SNPs have been uncovered in several human populations. However, the huge amount of SNPs bring new challenges in subsequent analysis. In reality, a number of SNPs may not be...
Topics
- Genome-Wide Association Study
- Genotype
- Haplotypes
- Humans
- Linkage Disequilibrium
- Models, Statistical
- Oligonucleotide Array Sequence Analysis
- Polymorphism, Single Nucleotide