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Article

The class III POU domain protein Brn-1 can fully replace the related Oct-6 during schwann cell development and myelination.

Molecular and cellular biology - 1 Mar 2005

Friedrich Ralf P, Schlierf Beate, Tamm Ernst R, Bösl Michael R, Wegner Michael

Abstract excerpt

For differentiation, Schwann cells rely on the class III POU domain transcription factor Oct-6, which is expressed transiently when Schwann cells have established a one-to-one relation with axons but have not yet started to myelinate. Loss of Oct-6 leads to a transient arrest in this promyelinating stage and a delay in myelination. Although the closely related POU domain protein Brn-2 is coexpressed with Oct-6 in...

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Identifiers

PMID: 15713637
DOI: 10.1128/MCB.25.5.1821-1829.2005
PMCID: PMC549364

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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