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Article

Replacement of related POU transcription factors leads to severe defects in mouse forebrain development.

Developmental biology - 15 Aug 2009

Wolf Michael, Lommes Petra, Sock Elisabeth, Reiprich Simone, Friedrich Ralf P, Kriesch Jana, Stolt C Claus, Bermingham John R, Wegner Michael

Abstract excerpt

Related transcription factors of the POU protein family show extensive overlap of expression in vivo and exhibit very similar biochemical properties in vitro. To study functional equivalence of class III POU proteins in vivo, we exchanged the Oct-6 gene by Brn-1 in the mouse. Brn-1 can fully replace Oct-6 in Schwann cells and rescue peripheral nervous system development in these mice. The same mice, however,...

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Identifiers

PMID: 19527706
DOI: 10.1016/j.ydbio.2009.06.011

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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