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Article

A cell type-specific allele of the POU gene Oct-6 reveals Schwann cell autonomous function in nerve development and regeneration.

The EMBO journal - 2 Sept 2002

Ghazvini Merhnaz, Mandemakers Wim, Jaegle Martine, Piirsoo Marko, Driegen Siska, Koutsourakis Manousos, Smit Xsander, Grosveld Frank, Meijer Dies

Abstract excerpt

While an important role for the POU domain transcription factor Oct-6 in the developing peripheral nerve has been well established, studies into its exact role in nerve development and regeneration have been hampered by the high mortality rate of newborn Oct-6 mutant animals. In this study we have generated a Schwann cell-specific Oct-6 allele through deletion of the Schwann cell-specific enhancer element (SCE)...

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Identifiers

PMID: 12198163
DOI: 10.1093/emboj/cdf475
PMCID: PMC125415

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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A cell type-specific allele of the POU gene Oct-6 reveals Schwann cell autonomous function in nerve development and regeneration.PMID 12198163Read ↗

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