Article
A G protein-coupled receptor is essential for Schwann cells to initiate myelination.
Science (New York, N.Y.) - 11 Sept 2009
Monk Kelly R, Naylor Stephen G, Glenn Thomas D, Mercurio Sara, Perlin Julie R, Dominguez Claudia, Moens Cecilia B, Talbot William S
Abstract excerpt
The myelin sheath allows axons to conduct action potentials rapidly in the vertebrate nervous system. Axonal signals activate expression of specific transcription factors, including Oct6 and Krox20, that initiate myelination in Schwann cells. Elevation of cyclic adenosine monophosphate (cAMP) can mimic axonal contact in vitro, but the mechanisms that regulate cAMP levels in vivo are unknown. Using mutational...
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