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Article

Micronucleated erythrocyte frequency in control and azidothymidine-treated Tk+/+, Tk+/- and Tk-/- mice.

Mutation research - 1 Mar 2005

Dobrovolsky Vasily N, McGarrity Lynda J, VonTungeln Linda S, Mittelstaedt Roberta A, Morris Suzanne M, Beland Frederick A, Heflich Robert H

Abstract excerpt

The first step in the activation of the anti-retroviral nucleoside analogue azidothymidine (AZT) involves its conversion to a 5'-monophosphate. In this study, we have evaluated the role of cytosolic thymidine kinase (Tk), the major enzyme involved in phosphorylating thymidine and its analogues, in the nuclear DNA damage produced by AZT in neonatal mice. Tk+/+, Tk+/- and Tk-/- mice were treated intraperitoneally...

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Source

Identifiers

PMID: 15708581
DOI: 10.1016/j.mrfmmm.2004.11.006

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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