Article
Analysis of mutations in the Tk gene of Tk(+/-) mice treated as neonates with 3'-azido-3'-deoxythymidine (AZT).
Mutation research - 22 Mar 2004
Mittelstaedt Roberta A, Von Tungeln Linda S, Shaddock Joseph G, Dobrovolsky Vasily N, Beland Frederick A, Heflich Robert H
Abstract excerpt
Mother-to-child transmission of the human immunodeficiency virus (HIV) is reduced by perinatal treatment with the antiretroviral nucleoside analogue 3'-azido-3'-deoxythymidine (AZT, zidovudine). AZT, however, is genotoxic and carcinogenic in mice when administered either transplacentally or neonatally, suggesting a possible cancer risk for children later in life. In a previous study we found that treating...
Topics
- Alleles
- Animals
- Animals, Newborn
- Anti-HIV Agents
- Chromosomes
- Clone Cells
- DNA Mutational Analysis
- Gene Deletion
- Heterozygote
- Loss of Heterozygosity
- Lymphocytes
- Mice
- Mice, Transgenic
- Microsatellite Repeats
- Mutation
- Recombination, Genetic
- Thymidine Kinase
- Zidovudine