Article
Mitochondrial toxicity in hearts of CD-1 mice following perinatal exposure to AZT, 3TC, or AZT/3TC in combination.
Environmental and molecular mutagenesis - 1 Jan 2000
Chan Sherine S L, Santos Janine H, Meyer Joel N, Mandavilli Bhaskar S, Cook Dennis L, McCash Consuelo L, Kissling Grace E, Nyska Abraham, Foley Julie F, van Houten Bennett, Copeland William C, Walker Vernon E, Witt Kristine L, Bishop Jack B
Abstract excerpt
Antiretroviral therapies based on nucleoside reverse transcriptase inhibitors (NRTIs), like zidovudine (3'-azido-3'-deoxythymidine; AZT) and lamivudine ((-)2',3'-dideoxy-3'-thiacytidine; 3TC), markedly reduce mother-to-child transmission of the human immunodeficiency virus (HIV). However, AZT induces damage in nuclear DNA of mice exposed in utero and postnatally, and mitochondrial DNA (mtDNA) damage has been...
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