Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Glioma invasion mediated by the p75 neurotrophin receptor (p75NTR/CD271) requires regulated interaction with PDLIM1

29 Jun 2015

Abstract excerpt

The invasive nature of glioblastoma renders them incurable by current therapeutic interventions. Using a novel invasive human glioma model, we previously identified the neurotrophin receptor p75(NTR) (aka CD271) as a mediator of glioma invasion. Herein, we provide evidence that preventing phosphorylation of p75(NTR) on S303 by pharmacological inhibition of PKA, or by a mutational strategy (S303G), cripples...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Axon Guidance and Neuronal Signaling
Share to Nerve injury and regeneration
Share to Neurofibromatosis and Schwannoma Cases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 26119933
DOI: 10.1038/onc.2015.199

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Glioma invasion mediated by the p75 neurotrophin receptor (p75NTR/CD271) requires regulated interaction with PDLIM1PMID 26119933Read ↗

The low affinity neurotrophin receptor CD271 regulates phenotype switching in melanomaSemantic proximity Read ↗

p75 neurotrophin receptor cleavage by α- and γ-secretases is required for neurotrophin-mediated proliferation of brain tumor-initiating cells.Semantic proximity Read ↗

CD271 is a molecular switch with divergent roles in melanoma and melanocyte developmentSemantic proximity Read ↗

Epidermal growth factor receptor - mediated signal transduction in the development and therapy of gliomas.Semantic proximity Read ↗

Molecular pathways triggering glioma cell invasionSemantic proximity Read ↗

A proinvasive role for the Ca<sup>2+</sup>‐activated K<sup>+</sup> channel KCa3.1 in malignant gliomaSemantic proximity Read ↗

Global Proteome and Phospho-proteome Analysis of Merlin-deficient Meningioma and Schwannoma Identifies PDLIM2 as a Novel Therapeutic TargetSemantic proximity Read ↗

CD271 Confers an Invasive and Metastatic Phenotype of Head and Neck Squamous Cell Carcinoma through the Upregulation of Slug.Semantic proximity Read ↗

Reciprocal regulation of Abl kinase by Crk Y251 and Abi1 controls invasive phenotypes in glioblastoma.Semantic proximity Read ↗

PDGFRA K385 mutants in myxoid glioneuronal tumors promote receptor dimerization and oncogenic signaling.Semantic proximity Read ↗

MAP-ing glioma invasion: Mitogen-activated protein kinase kinase 3 and p38 drive glioma invasion and progression and predict patient survivalSemantic proximity Read ↗

Genetic manipulation of adhesion GPCR CD97/ADGRE5 modulates invasion in patient-derived glioma stem cellsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.