Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

p75 neurotrophin receptor cleavage by α- and γ-secretases is required for neurotrophin-mediated proliferation of brain tumor-initiating cells.

The Journal of biological chemistry - 21 Mar 2014

Forsyth Peter A, Krishna Niveditha, Lawn Samuel, Valadez J Gerardo, Qu Xiaotao, Fenstermacher David A, Fournier Michelle, Potthast Lisa, Chinnaiyan Prakash, Gibney Geoffrey T, Zeinieh Michele, Barker Philip A, Carter Bruce D, Cooper Michael K, Kenchappa Rajappa S

Abstract excerpt

Malignant gliomas are highly invasive, proliferative, and resistant to treatment. Previously, we have shown that p75 neurotrophin receptor (p75NTR) is a novel mediator of invasion of human glioma cells. However, the role of p75NTR in glioma proliferation is unknown. Here we used brain tumor-initiating cells (BTICs) and show that BTICs express neurotrophin receptors (p75NTR, TrkA, TrkB, and TrkC) and their ligands...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Amyloid Precursor Protein Secretases
Share to Brain Neoplasms

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Cell Proliferation

Share to Gene Knockdown Techniques

Share to Glioma

Share to Neoplastic Stem Cells

Share to Nerve Growth Factors

Share to Receptor, Nerve Growth Factor

Source

Open in PubMed Open full text

Identifiers

PMID: 24519935
DOI: 10.1074/jbc.M113.513762
PMCID: PMC3961639

Genes

NGF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

p75 neurotrophin receptor cleavage by α- and γ-secretases is required for neurotrophin-mediated proliferation of brain tumor-initiating cells.PMID 24519935Read ↗

Glioma invasion mediated by the p75 neurotrophin receptor (p75NTR/CD271) requires regulated interaction with PDLIM1Semantic proximity Read ↗

Evidence for a critical role of the tumor necrosis factor alpha convertase (TACE) in ectodomain shedding of the p75 neurotrophin receptor (p75NTR).Semantic proximity Read ↗

Cutting Edge: ERK1 Mediates the Autocrine Positive Feedback Loop of TGF-β and Furin in Glioma-Initiating CellsSemantic proximity Read ↗

ADAM-9 is a novel mediator of tenascin-C-stimulated invasiveness of brain tumor–initiating cellsSemantic proximity Read ↗

Trk Receptor Expression and Inhibition in NeuroblastomasSemantic proximity Read ↗

CNTF receptor subunit α as a marker for glioma tumor-initiating cells and tumor grade: laboratory investigation.Semantic proximity Read ↗

Constitutively active TrkB confers an aggressive transformed phenotype to a neural crest-derived cell line.Semantic proximity Read ↗

Expression and pharmacological inhibition of TrkB and EGFR in glioblastomaSemantic proximity Read ↗

BDNF: An Oncogene or Tumor Suppressor?Semantic proximity Read ↗

MicroRNA-296-5p Promotes Invasiveness through Downregulation of Nerve Growth Factor Receptor and Caspase-8Semantic proximity Read ↗

Cleavage of p75 neurotrophin receptor by alpha-secretase and gamma-secretase requires specific receptor domains.Semantic proximity Read ↗

Activation of NOTCH Signaling by Tenascin-C Promotes Growth of Human Brain Tumor-Initiating CellsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.