Article

Blocking GRP/GRP-R Signaling Decreases Expression of Androgen Receptor Splice Variants and Inhibits Tumor Growth in Castration-resistant Prostate Cancer

2021-02-05

Abstract excerpt

<h4>Background: </h4> Clinical management of castration-resistant prostate cancer (CRPC) resulting from androgen deprivation therapy (ADT) remains challenging. Previously, we have reported that long-term ADT increases the neuroendocrine (NE) hormone – Gastrin Releasing Peptide (GRP) and its receptor (GRP-R) expression in prostate cancer (PC) cells. Further, we demonstrated that activation of GRP/GRP-R signaling in...

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Literature Corpus work: 9ac4d34f-7515-5881-94e9-b757808cf500
DOI: 10.21203/rs.3.rs-164004/v1

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