Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Mutant p53 initiates a feedback loop that involves Egr-1/EGF receptor/ERK in prostate cancer cells.

Oncogene - 6 May 2010

Sauer L, Gitenay D, Vo C, Baron V T

Abstract excerpt

Early growth response-1 (Egr-1) is overexpressed in human prostate tumors and contributes to cancer progression. On the other hand, mutation of p53 is associated with advanced prostate cancer, as well as with metastasis and hormone independence. This study shows that in prostate cell lines in culture, Egr-1 overexpression correlated with an alteration of p53 activity because of the expression of SV40 large...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Early Growth Response Protein 1
Share to ErbB Receptors
Share to Extracellular Signal-Regulated MAP Kinases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Feedback, Physiological

Share to MAP Kinase Signaling System

Share to Mitogen-Activated Protein Kinase Kinases

Share to Prostatic Neoplasms

Share to Tumor Suppressor Protein p53

Source

Open in PubMed Open full text

Identifiers

PMID: 20190820
DOI: 10.1038/onc.2010.24
PMCID: PMC2865566

Genes

EGFR
EGF
EGR1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Mutant p53 initiates a feedback loop that involves Egr-1/EGF receptor/ERK in prostate cancer cells.PMID 20190820Read ↗

EGFR mutation up-regulates EGR1 expression through the ERK pathway.Semantic proximity Read ↗

Androgen-independent growth of LNCaP prostate cancer cells is mediated by gain-of-function mutant p53.Semantic proximity Read ↗

Transactivation of the EGR1 gene contributes to mutant p53 gain of function.Semantic proximity Read ↗

Egr1 regulates the coordinated expression of numerous EGF receptor target genes as identified by ChIP-on-chipSemantic proximity Read ↗

p53 expression controls prostate cancer sensitivity to chemotherapy and the MDM2 inhibitor Nutlin-3Semantic proximity Read ↗

Egr1 Signaling in Prostate CancerSemantic proximity Read ↗

Egr1 Promotes Growth and Survival of Prostate Cancer CellsSemantic proximity Read ↗

TMPRSS2-ERG Controls Luminal Epithelial Lineage and Antiandrogen Sensitivity in PTEN and TP53 -Mutated Prostate CancerSemantic proximity Read ↗

Profiling of gene expression changes caused by p53 gain-of-function mutant alleles in prostate cancer cells.Semantic proximity Read ↗

Inhibition of Egr-1 expression reverses transformation of prostate cancer cells in vitro and in vivo.Semantic proximity Read ↗

The p75NTR mediates a bifurcated signal transduction cascade through the NF kappa B and JNK pathways to inhibit cell survival.Semantic proximity Read ↗

The unfolded protein response during prostate cancer developmentSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.