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Article

PTEN downregulates p75NTR expression by decreasing DNA-binding activity of Sp1.

Biochemical and biophysical research communications - 13 Feb 2009

Rankin Sherri L, Guy Clifford S, Mearow Karen M

Abstract excerpt

p75NTR is expressed throughout the nervous system and its dysregulation is associated with pathological conditions. We have recently demonstrated a signalling cascade initiated by laminin (LN), which upregulates PTEN and downregulates p75NTR. Here we investigate the mechanism by which PTEN modulates p75NTR. Studies using PTEN mutants show that its protein phosphatase activity directly modulates p75NTR protein...

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Source

Identifiers

PMID: 19114034
DOI: 10.1016/j.bbrc.2008.12.075

Genes

PTEN

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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