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Article

Activation of GRP/GRP-R signaling contributes to castration-resistant prostate cancer progression.

Oncotarget - 20 Sept 2016

Qiao Jingbo, Grabowska Magdalena M, Forestier-Roman Ingrid S, Mirosevich Janni, Case Thomas C, Chung Dai H, Cates Justin M M, Matusik Robert J, Manning H Charles, Jin Renjie

Abstract excerpt

Numerous studies indicate that androgen receptor splice variants (ARVs) play a critical role in the development of castration-resistant prostate cancer (CRPC), including the resistance to the new generation of inhibitors of androgen receptor (AR) action. Previously, we demonstrated that activation of NF-κB signaling increases ARVs expression in prostate cancer (PC) cells, thereby promoting progression to CRPC....

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 27542219
DOI: 10.18632/oncotarget.11326
PMCID: PMC5308703

Genes

GRP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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