Article
Genome wide analysis of transcript levels after perturbation of the EGFR pathway in the Drosophila ovary.
Developmental dynamics : an official publication of the American Association of Anatomists - 1 Mar 2005
Jordan Katherine C, Hatfield Steven D, Tworoger Michael, Ward Ellen J, Fischer Karin A, Bowers Stuart, Ruohola-Baker Hannele
Abstract excerpt
Defects in the epidermal growth factor receptor (EGFR) pathway can lead to aggressive tumor formation. Activation of this pathway during normal development produces multiple outcomes at the cellular level, leading to cellular differentiation and cell cycle activation. To elucidate the downstream events induced by this pathway, we used genome-wide cDNA microarray technology to identify potential EGFR targets in...
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