Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Characterization of two highly polymorphic human tryptase loci and comparison with a newly discovered monkey tryptase ortholog.

Pharmacogenetics - 1 Jul 2000

Guida M, Riedy M, Lee D, Hall J

Abstract excerpt

Tryptases are serine proteases involved in mast cell-mediated inflammatory responses which represent potential targets of drugs against diseases such as asthma, arthritis and inflammatory bowel disease. In order to interpret pharmacodynamic data on the tryptase inhibitors undergoing clinical trials, we defined the genetic variability of the tryptase 1 (TPS1) and tryptase 2 (TPS2) loci by screening a reference...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Chymases
Share to Genetic Markers
Share to Macaca fascicularis

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Mast Cells

Share to Sequence Homology, Amino Acid

Share to Sequence Homology, Nucleic Acid

Share to Serine Endopeptidases

Share to Tryptases

Source

Identifiers

PMID: 10898108
DOI: 10.1097/00008571-200007000-00002

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Characterization of two highly polymorphic human tryptase loci and comparison with a newly discovered monkey tryptase ortholog.PMID 10898108Read ↗

Human subjects are protected from mast cell tryptase deficiency despite frequent inheritance of loss-of-function mutations.Semantic proximity Read ↗

Tryptase: genetic and functional considerations.Semantic proximity Read ↗

Resolving the genetics of human tryptases: implications for health, disease, and clinical use as a biomarkerSemantic proximity Read ↗

Characterization of Human γ-Tryptases, Novel Members of the Chromosome 16p Mast Cell Tryptase and Prostasin Gene FamiliesSemantic proximity Read ↗

A targeted amplicon next-generation sequencing assay for tryptase genotyping to support personalized therapy in mast cell-related disorders.Semantic proximity Read ↗

Mast cell tryptases in allergic inflammation and immediate hypersensitivity.Semantic proximity Read ↗

Hereditary alpha-tryptasemiaSemantic proximity Read ↗

Genetic deficiency of human mast cell alpha-tryptase.Semantic proximity Read ↗

Elevated basal serum tryptase identifies a multisystem disorder associated with increased TPSAB1 copy numberSemantic proximity Read ↗

Hereditary Alpha-Tryptasemia and Mastocytosis: What We Know and What We Need To Learn.Semantic proximity Read ↗

Hereditary Alpha Tryptasemia: Genotyping and Associated Clinical Features.Semantic proximity Read ↗

Characterization of Genes Encoding Known and Novel Human Mast Cell Tryptases on Chromosome 16p13.3Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.