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Article

The prognostic significance of K-ras, p53, and APC mutations in colorectal carcinoma.

Gut - 1 Sept 2005

Conlin A, Smith G, Carey F A, Wolf C R, Steele R J C

Abstract excerpt

BACKGROUND: Accumulation of molecular alterations, including mutations in Kirsten-ras (K-ras), p53, and adenomatous polyposis coli (APC), contribute to colorectal carcinogenesis. Our group has previously characterised a panel of sporadic colorectal adenocarcinomas for mutations in these three genes and has shown that p53 and K-ras mutations rarely occur in the same colorectal tumour. This suggests that mutations...

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Identifiers

PMID: 15843421
DOI: 10.1136/gut.2005.066514
PMCID: PMC1774675

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APC

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Source receipt: pubmed, retrieved 7 Sept 2026.

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