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Article

Immunohistochemical analysis of the mutant epidermal growth factor, deltaEGFR, in glioblastoma.

Brain tumor pathology - 1 Jan 2004

Nishikawa Ryo, Sugiyama Tatsuya, Narita Yoshitaka, Furnari Frank, Cavenee Webster K, Matsutani Masao

Abstract excerpt

The naturally occurring mutated form of the epidermal growth factor receptor, deltaEGFR (also named EGFRvIII and de2-7EGFR), greatly enhances glioblastoma (GBM) cell growth in vivo through several activities, such as down-regulating p27 and up-regulating BclX(L) while increasing signaling through the RAS-MAPK and PI3-K cascades. More than half of GBMs, especially of the de novo type, overexpress EGFR, and 50%-70%...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 15700833
DOI: 10.1007/BF02484510

Genes

EGFR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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