Article
A common mutant epidermal growth factor receptor confers enhanced tumorigenicity on human glioblastoma cells by increasing proliferation and reducing apoptosis.
Cancer research - 1 Nov 1996
Nagane M, Coufal F, Lin H, Bögler O, Cavenee W K, Huang H J
Abstract excerpt
Alterations of the EGFR gene occur frequently in human gliomas where the most common is an in-frame deletion of exons 2-7 from the extracellular domain, resulting in a truncated mutant receptor (deltaEGFR or de 2-7 EGFR). We previously demonstrated that introduction of deltaEGFR into human U87MG...
Topics
- Animals
- Apoptosis
- Cell Division
- ErbB Receptors
- Glioblastoma
- Humans
- Mice
- Mice, Inbred BALB C
- Mutation
- Proto-Oncogene Proteins c-bcl-2
- Tumor Cells, Cultured