Article
Aberrant receptor signaling in human malignant gliomas: mechanisms and therapeutic implications.
Cancer letters - 1 Jan 2001
Nagane M, Lin H, Cavenee W K, Huang H J
Abstract excerpt
Alterations of the epidermal growth factor receptor (EGFR) occur frequently in malignant gliomas through gene amplification or rearrangement, especially in a large fraction of de novo type glioblastomas. The most common of these mutant EGFRs (variously named de2-7 EGFR, deltaEGFR or EGFRvIII) lacks a portion of the extracellular ligand-binding domain. Here, we review the evidence that shows that expression of...
Topics
- Apoptosis
- Drug Resistance, Neoplasm
- ErbB Receptors
- Glioma
- Humans
- Mutation
- Quinazolines
- Signal Transduction
- Tyrphostins