Article
Differential gene expression analysis reveals generation of an autocrine loop by a mutant epidermal growth factor receptor in glioma cells.
Cancer research - 15 Jan 2006
Ramnarain Deepti B, Park Seongmi, Lee Diana Y, Hatanpaa Kimmo J, Scoggin Shane O, Otu Hasan, Libermann Towia A, Raisanen Jack M, Ashfaq Raheela, Wong Eric T, Wu Julian, Elliott Robert, Habib Amyn A
Abstract excerpt
The epidermal growth factor receptor (EGFR) gene is commonly amplified and rearranged in glioblastoma multiforme leading to overexpression of wild-type and mutant EGFRs. Expression of wild-type EGFR ligands, such as transforming growth factor-alpha (TGF-alpha) or heparin-binding EGF (HB-EGF), is also often increased in gliomas resulting in an autocrine loop that contributes to the growth autonomy of glioma cells....
Topics
- Autocrine Communication
- Brain Neoplasms
- Cell Transformation, Neoplastic
- ErbB Receptors
- Gene Expression Profiling
- Glioblastoma
- Humans
- Immunohistochemistry
- Mutation
- Signal Transduction
- Up-Regulation