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Article

Mutant EGFR is required for maintenance of glioma growth in vivo, and its ablation leads to escape from receptor dependence.

Proceedings of the National Academy of Sciences of the United States of America - 9 Feb 2010

Mukasa Akitake, Wykosky Jill, Ligon Keith L, Chin Lynda, Cavenee Webster K, Furnari Frank

Abstract excerpt

Epidermal growth factor receptor (EGFR) gene amplification is the most common genetic alteration in high-grade glioma, and approximately 50% of EGFR-amplified tumors also harbor a constitutively active mutant form of the receptor, DeltaEGFR. Although DeltaEGFR greatly enhances tumor growth and is...

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Identifiers

PMID: 20133782
DOI: 10.1073/pnas.0914356107
PMCID: PMC2823874

Genes

EGFR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-20133782-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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