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Article

Prospective study of N‐acetyltransferase‐2 genotypes, meat intake, smoking and risk of colorectal cancer

7 Feb 2005

Abstract excerpt

Consumption of red meat has been associated with elevated risk of colorectal cancer; however, mechanisms underlying this relationship are not well established. N-acetyltransferase 2 (NAT2) appears to activate carcinogenic heterocyclic amines found in meat as well as cigarette smoke. Genetic variation in this enzyme, associated with rapid acetylation, may modulate the influence of meat intake on cancer risk. We...

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PMID: 15700302
DOI: 10.1002/ijc.20890

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