Article
N-acetyl transferase 2 genotypes, meat intake and breast cancer risk.
International journal of cancer - 5 Jan 1999
Gertig D M, Hankinson S E, Hough H, Spiegelman D, Colditz G A, Willett W C, Kelsey K T, Hunter D J
Abstract excerpt
Heterocyclic amines (HAs) are carcinogens produced by high-temperature cooking of meat and animal protein; metabolism of HA is influenced by polymorphisms in the N-acetyltransferase-2 (NAT-2) gene. Data from a variety of sources suggest that HA may play a role in human carcinogenesis. We examined the associations between meat intake and cooking method, acetylator genotype and breast cancer risk in a sub-cohort of...
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