Article
Red meat intake, NAT2, and risk of colorectal cancer: a pooled analysis of 11 studies.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology - 1 Jan 2015
Ananthakrishnan Ashwin N, Du Mengmeng, Berndt Sonja I, Brenner Hermann, Caan Bette J, Casey Graham, Chang-Claude Jenny, Duggan David, Fuchs Charles S, Gallinger Steven, Giovannucci Edward L, Harrison Tabitha A, Hayes Richard B, Hoffmeister Michael, Hopper John L, Hou Lifang, Hsu Li, Jenkins Mark A, Kraft Peter, Ma Jing, Nan Hongmei, Newcomb Polly A, Ogino Shuji, Potter John D, Seminara Daniela, Slattery Martha L, Thornquist Mark, White Emily, Wu Kana, Peters Ulrike, Chan Andrew T
Abstract excerpt
BACKGROUND: Red meat intake has been associated with risk of colorectal cancer, potentially mediated through heterocyclic amines. The metabolic efficiency of N-acetyltransferase 2 (NAT2) required for the metabolic activation of such amines is influenced by genetic variation. The interaction between red meat intake, NAT2 genotype, and colorectal cancer has been inconsistently reported. METHODS: We used pooled...
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