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Article

Effect of NAT1 and NAT2 genetic polymorphisms on colorectal cancer risk associated with exposure to tobacco smoke and meat consumption.

Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology - 1 Jan 2006

Lilla Carmen, Verla-Tebit Emaculate, Risch Angela, Jäger Birgit, Hoffmeister Michael, Brenner Hermann, Chang-Claude Jenny

Abstract excerpt

N-Acetyltransferases 1 and 2 (NAT1 and NAT2), both being highly polymorphic, are involved in the metabolism of aromatic and heterocyclic aromatic amines present in cigarette smoke and red meat cooked by high-temperature cooking techniques. We investigated the effect of differences in acetylation capacity, determined by NAT1 and NAT2 genotypes, on colorectal cancer risk associated with exposure to tobacco smoke or...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 16434594
DOI: 10.1158/1055-9965.EPI-05-0618

Genes

NAT2
NAT1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Effect of NAT1 and NAT2 genetic polymorphisms on colorectal cancer risk associated with exposure to tobacco smoke and meat consumption.PMID 16434594Read ↗

Prospective study of NAT1 and NAT2 polymorphisms, tobacco smoking and meat consumption and risk of colorectal cancer.Semantic proximity Read ↗

Prospective study of N‐acetyltransferase‐2 genotypes, meat intake, smoking and risk of colorectal cancerSemantic proximity Read ↗

Investigation of interaction between N-acetyltransferase 2 and heterocyclic amines as potential risk factors for colorectal cancer.Semantic proximity Read ↗

Interaction between Red Meat Intake and NAT2 Genotype in Increasing the Risk of Colorectal Cancer in Japanese and African Americans.Semantic proximity Read ↗

Meat and heterocyclic amine intake, smoking, NAT1 and NAT2 polymorphisms, and colorectal cancer risk in the multiethnic cohort study.Semantic proximity Read ↗

A prospective study of N-acetyltransferase genotype, red meat intake, and risk of colorectal cancer.Semantic proximity Read ↗

Molecular genetics and epidemiology of the NAT1 and NAT2 acetylation polymorphisms.Semantic proximity Read ↗

NAT1 and NAT2 genetic polymorphisms and environmental exposure as risk factors for oesophageal squamous cell carcinoma: a case-control study.Semantic proximity Read ↗

N-Acetyltransferase 2 genetic polymorphisms and risk of colorectal cancer.Semantic proximity Read ↗

Combined effects of well-done red meat, smoking, and rapid N-acetyltransferase 2 and CYP1A2 phenotypes in increasing colorectal cancer risk.Semantic proximity Read ↗

NAT2, meat consumption and colorectal cancer incidence: an ecological study among 27 countries.Semantic proximity Read ↗

Red meat intake, NAT2, and risk of colorectal cancer: a pooled analysis of 11 studies.Semantic proximity Read ↗

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