Article
Investigation of interaction between N-acetyltransferase 2 and heterocyclic amines as potential risk factors for colorectal cancer.
Carcinogenesis - 1 Feb 2003
Barrett J H, Smith G, Waxman R, Gooderham N, Lightfoot T, Garner R C, Augustsson K, Wolf C R, Bishop D T, Forman D
Abstract excerpt
Fast N-acetyltransferase 2 (NAT2) acetylators may be at increased risk of colorectal cancer through the activation of carcinogenic heterocyclic amines (HA), which are produced by meat cooked at high temperatures and are found in cigarette smoke. A study of 500 incident colorectal cancer cases and population controls, matched for age, sex and general practitioner, was conducted in the UK to investigate this...
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