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Article

A prospective study of N-acetyltransferase genotype, red meat intake, and risk of colorectal cancer.

Cancer research - 1 Aug 1998

Chen J, Stampfer M J, Hough H L, Garcia-Closas M, Willett W C, Hennekens C H, Kelsey K T, Hunter D J

Abstract excerpt

Carcinogenic heterocyclic amines are activated by N-acetyltransferase (NAT) enzymes, encoded by NAT1 and NAT2, to genotoxic compounds that can form DNA adducts in the colon epithelium. We have examined the relation of polymorphisms in the genes coding for both enzymes to risk of colorectal cancer and the gene-environment interaction with red meat intake among participants in the prospective Physicians' Health...

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Source

Identifiers

PMID: 9699660

Genes

NAT1
NAT2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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A prospective study of N-acetyltransferase genotype, red meat intake, and risk of colorectal cancer.PMID 9699660Read ↗

Prospective study of N‐acetyltransferase‐2 genotypes, meat intake, smoking and risk of colorectal cancerSemantic proximity Read ↗

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Interaction between Red Meat Intake and NAT2 Genotype in Increasing the Risk of Colorectal Cancer in Japanese and African Americans.Semantic proximity Read ↗

Prospective study of NAT1 and NAT2 polymorphisms, tobacco smoking and meat consumption and risk of colorectal cancer.Semantic proximity Read ↗

Polymorphisms of cytochrome P450 1A2 and N-acetyltransferase genes, meat consumption, and risk of colorectal cancer.Semantic proximity Read ↗

Meat, metabolic genotypes and risk for colorectal cancer.Semantic proximity Read ↗

Effect of NAT1 and NAT2 genetic polymorphisms on colorectal cancer risk associated with exposure to tobacco smoke and meat consumption.Semantic proximity Read ↗

Meat and heterocyclic amine intake, smoking, NAT1 and NAT2 polymorphisms, and colorectal cancer risk in the multiethnic cohort study.Semantic proximity Read ↗

Polymorphisms of glutathione-S-transferase and arylamine N-acetyltransferase enzymes and susceptibility to colorectal cancer.Semantic proximity Read ↗

Combined effects of well-done red meat, smoking, and rapid N-acetyltransferase 2 and CYP1A2 phenotypes in increasing colorectal cancer risk.Semantic proximity Read ↗

Investigation of interaction between N-acetyltransferase 2 and heterocyclic amines as potential risk factors for colorectal cancer.Semantic proximity Read ↗

Role of acetylation in colorectal cancer.Semantic proximity Read ↗

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