A prospective study of N-acetyltransferase genotype, red meat intake, and risk of colorectal cancer.

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Article

A prospective study of N-acetyltransferase genotype, red meat intake, and risk of colorectal cancer.

Cancer research - 1 Aug 1998

Chen J, Stampfer M J, Hough H L, Garcia-Closas M, Willett W C, Hennekens C H, Kelsey K T, Hunter D J

Abstract excerpt

Carcinogenic heterocyclic amines are activated by N-acetyltransferase (NAT) enzymes, encoded by NAT1 and NAT2, to genotoxic compounds that can form DNA adducts in the colon epithelium. We have examined the relation of polymorphisms in the genes coding for both enzymes to risk of colorectal cancer...

Topics

Adult
Aged
Aged, 80 and over
Alleles
Animals
Arylamine N-Acetyltransferase
Cattle
Colorectal Neoplasms
Disease Susceptibility
Follow-Up Studies
Genotype
Humans
Isoenzymes
Male
Meat
Middle Aged
Polymorphism, Genetic
Prospective Studies

Source

Open in PubMed

Identifiers

PMID: 9699660

Genes

NAT1
NAT2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9699660-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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