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Article

The transcription factor Sox9 is degraded by the ubiquitin-proteasome system and stabilized by a mutation in a ubiquitin-target site.

Matrix biology : journal of the International Society for Matrix Biology - 1 Jan 2005

Akiyama Haruhiko, Kamitani Tetsu, Yang Xiaohong, Kandyil Roshini, Bridgewater Laura C, Fellous Marc, Mori-Akiyama Yuko, de Crombrugghe Benoit

Abstract excerpt

Sox9 is a transcription factor that is critical for chondrogenesis, testis determination, and development of several other organs in vertebrates. Thus the levels of Sox9 protein and its activity may be tightly regulated. Here we show that inhibitors of the 26S proteasome increase both the levels of Sox9 protein and its transcriptional activity measured with Col2a1 promoter/enhancer construct in RCS cells and...

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Source

Identifiers

PMID: 15694126
DOI: 10.1016/j.matbio.2004.10.002

Genes

AMH

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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