Article
Repression of SOX6 transcriptional activity by SUMO modification.
FEBS letters - 20 Feb 2006
Fernández-Lloris R, Osses N, Jaffray E, Shen L N, Vaughan O A, Girwood D, Bartrons R, Rosa J L, Hay R T, Ventura F
Abstract excerpt
SOX6 plays key functions in several developmental processes, including neurogenesis and skeleton formation. In this report, we show that SOX6 is modified in vitro and in vivo by small ubiquitin-related modifier (SUMO) on two distinct sites. Mutation of both sites abolished SOX6 sumoylation and increased SOX6 transcriptional activity. SUMO dependent repression of SOX6 transcription was promoted by UBC9 whereas...
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